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What is it? Progesterone is a steroid hormone made in the adrenal glands, the ovaries (and the testes in men), and—during pregnancy—the placenta. After ovulation each month, the ovary releases progesterone to prepare the uterus for a possible pregnancy. If the egg is fertilized, the placenta eventually takes over progesterone production. If not, progesterone levels fall… and your period begins. Structural representation of progesterone, a steroid hormone with the chemical for